通过掺入活化酯的生物电子学用多功能聚(3,4-亚乙基二氧噻吩)聚电解质《Chemistry of Materials》

Versatile Poly(3,4-ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester

Joshua Tropp, Abijeet Singh Mehta, Xudong Ji, Abhijith Surendran, Ruiheng Wu, Emily A. Schafer, Manideep M. Reddy, Shiv P. Patel, Anthony J. Petty II, and Jonathan Rivnay*

Department of Biomedical Engineering, Center for Advanced Regenerative Engineering, Simpson Querrey Institute, Northwestern University, Evanston, Illinois 60208, United States

Chem. Mater. 2022, XXXX, XXX, XXX-XXX

Publication Date: December 19, 2022

https://doi.org/10.1021/acs.chemmater.2c02315

Abstract

The field of bioelectronics leverages the optoelectronic properties of synthetic materials to interface with living systems. These applications require materials that are conductive, aqueous-processible, biocompatible, and can be chemically modified for biofunctionalization. While conjugated polymers and polyelectrolytes have been reported that demonstrate several of these features, materials that offer each of these properties simultaneously are rare. Here, we develop copolymers of anionic polyelectrolyte poly(4-(2,3-dihydrothieno [3,4-b]-[1,4]dioxin-2-yl-methoxy)-1-butanesulfonic acid, sodium salt) (PEDOT-S) containing structural units with amine-reactive N-hydroxysuccinimide (NHS)-esters. The reported PEDOT-NHS copolymers demonstrate water solubility and electrical conductivities similar to previously reported PEDOT-S, as well as the ability to bind important amine-rich biomaterials. Furthermore, the PEDOT-NHS copolymers were biocompatible and hemocompatible and therefore show promise for next-generation bioelectronic and regenerative engineering applications.

SUBJECTS:

• Animal derived food,

• Biocompatibility,

• Biomaterials,

• Copolymers,

• Polymers