两性离子生物材料《Chemical Reviews》

Zwitterionic Biomaterials

Qingsi Li, Chiyu Wen, Jing Yang, Xianchi Zhou, Yingnan Zhu, Jie Zheng, Gang Cheng, Jie Bai, Tong Xu, Jian Ji, Shaoyi Jiang*, Lei Zhang*, and Peng Zhang*

MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China

Chem. Rev. 2022, XXXX, XXX, XXX-XXX

Publication Date: October 6, 2022

https://doi.org/10.1021/acs.chemrev.2c00344

REVIEW

Abstract

The term “zwitterionic polymers” refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these oppositely charged groups are equally distributed at the molecular level, the molecules exhibit an overall neutral charge with a strong hydration effect via ionic solvation. The strong hydration effect constitutes the foundation of a series of exceptional properties of zwitterionic materials, including resistance to protein adsorption, lubrication at interfaces, promotion of protein stabilities, antifreezing in solutions, etc. As a result, zwitterionic materials have drawn great attention in biomedical and engineering applications in recent years. In this review, we give a comprehensive and panoramic overview of zwitterionic materials, covering the fundamentals of hydration and nonfouling behaviors, different types of zwitterionic surfaces and polymers, and their biomedical applications.