聚酯类生物降解高分子 聚己内酯 聚乙丙交酯 聚乳酸 聚丙交酯 聚乙交酯 聚乙醇酸 PLGA PLA PCL PGA 简介

Polyesters (聚酯) are used in a number of Food and Drug Administration (FDA) approved therapeutic devices, owing to its biodegradability and biocompatibility. These polymers are degraded by hydrolysis of their ester linkages in the body to produce its original monomers, such as lactic acid and glycolic acid from PLGA, which are two by-products of various metabolic pathways.

PCL (聚己内酯）, Polycaprolactone is often used as an implantable biomaterial in long term implantable devices.

PLGA (聚乙丙交酯) - poly(lactide-co-glycolide) copolymer are available at a wide range of molecular weight (MW) and monomer (lactide to glycolide) molar ratios. Typical L to G feed ratios include 50:50, 65:35, 75:25 and 85:15. PLGA can be dissolved in a wide range of solvents - higher lactide polymers can be dissolved using chlorinated solvents whereas higher glycolide polymers will require the use of fluorinated solvents such as HFIP.

PLA (聚乳酸, 聚丙交酯), Poly(lactic acid) or polylactic acid or polylactide is a biodegradable aliphatic polyester. Due to the chiral center in the monomer (two L- or D- enantiomer forms), several PLA polymers exist such as isomerically pure poly-L-lactide (PLLA) and poly-D-lactide (PDLA) and the racemic mixture poly-D,L-lactide (PDLLA).

PGA (聚乙交酯、聚乙醇酸), Polyglycolide or poly(glycolic acid) has unusual solubility. In its high molecular weight form PGA is insoluble in almost all common organic solvents but could be soluble in highly fluorinated solvents like hexafluoroisopropanol (HFIP) and perfluoroacetone, while low molecular weight PGA is more soluble in common organic solvents.